Article
Age-dependent recombination rates in human pedigrees.
PLoS genetics - 1 Sept 2011
Hussin Julie, Roy-Gagnon Marie-Hélène, Gendron Roxanne, Andelfinger Gregor, Awadalla Philip
Abstract excerpt
In humans, chromosome-number abnormalities have been associated with altered recombination and increased maternal age. Therefore, age-related effects on recombination are of major importance, especially in relation to the mechanisms involved in human trisomies. Here, we examine the relationship between maternal age and recombination rate in humans. We localized crossovers at high resolution by using over 600,000...
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