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Article

Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors.

Nature immunology - 1 Mar 2021

Park Jang Hyun, Kim Hyun-Jin, Kim Chae Won, Kim Hyeon Cheol, Jung Yujin, Lee Hyun-Soo, Lee Yunah, Ju Young Seok, Oh Ji Eun, Park Sung-Hong, Lee Jeong Ho, Lee Sung Ki, Lee Heung Kyu

Abstract excerpt

The anatomic location and immunologic characteristics of brain tumors result in strong lymphocyte suppression. Consequently, conventional immunotherapies targeting CD8 T cells are ineffective against brain tumors. Tumor cells escape immunosurveillance by various mechanisms and tumor cell metabolism can affect the metabolic states and functions of tumor-infiltrating lymphocytes. Here, we discovered that brain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33574616
DOI: 10.1038/s41590-020-00860-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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