Article
Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria.
Cell calcium - 1 Nov 2011
Medic Nevenka, Desai Avanti, Komarow Hirsh, Burch Lauranell H, Bandara Geethani, Beaven Michael A, Metcalfe Dean D, Gilfillan Alasdair M
Abstract excerpt
Mast cells are considered the primary initiators of allergic diseases as a consequence of the release of multiple inflammatory mediators on activation. Although predominately activated through antigen-mediated aggregation of IgE-occupied-FcɛRI, they can also be induced to release mediators by other receptors and environmental stimuli. Based on studies conducted in the RBL 2H3 rodent mast cell line, the transient...
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