Article
Hereditary cancer and its clinical implications: a view.
Anticancer research - 1 Jan 2000
Den Otter W, Koten J W, Van der Vegt B J, Beemer F A, Boxma O J, De Graaf P W, Derkinderen D J, Hill F W, Huber J, Klein W R
Abstract excerpt
In hereditary cancers the responsible inherited cancer genes are defective (mutated) anti-oncogenes (tumour suppressor genes). This inherited mutation is present in all cells of the organism, and only leads to cancer if in a somatic cell a complete set of specific cancer mutations is accumulated. Since one defective anti-oncogene has been inherited, only three additional somatic cancer mutations are required,...
Topics
- Genes, Dominant
- Humans
- Mutation
- Neoplasms
- Oncogenes
- Suppression, Genetic