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Article

The cell-type-specificity of inherited predispositions to tumours: review and hypothesis.

Cancer letters - 28 Dec 2004

Bignold Leon P

Abstract excerpt

Most hereditary predispositions to tumours affect only one particular cell type of the body but the genes bearing the relevant germ-line mutation are not cell-type-specific. Some predisposition syndromes include increased risks of lesions (developmental or tumourous) of unrelated cell types, in any individual predisposed to the main lesion (e.g. osteosarcoma in patients predisposed to retinoblastoma). Other...

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PMID: 15533589
DOI: 10.1016/j.canlet.2004.07.037

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APC
PTEN
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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