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Article

Heritable one-hit events defining cancer prevention?

Cell cycle (Georgetown, Tex.) - 15 Aug 2013

Kopelovich Levy, Shea-Herbert Brittney

Abstract excerpt

Over 100 years ago (1902-1914) Theodor Boveri suggested a role for mutations in cancer. Boveri's ideas were derived from the then "just-emerging" chromosome theory of inheritance. While demonstrating chromosomal aberrations as a cause of genetic imbalance, Boveri suggested that possible causes of malignancy may include events such as aneuploidy that are now defined as gene mutations, asserting all the while that...

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Identifiers

PMID: 23907126
DOI: 10.4161/cc.25690
PMCID: PMC3865044

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