Article
MicroRNA-29 in aortic dilation: implications for aneurysm formation.
Circulation research - 28 Oct 2011
Boon Reinier A, Seeger Timon, Heydt Susanne, Fischer Ariane, Hergenreider Eduard, Horrevoets Anton J G, Vinciguerra Manlio, Rosenthal Nadia, Sciacca Sergio, Pilato Michele, van Heijningen Paula, Essers Jeroen, Brandes Ralf P, Zeiher Andreas M, Dimmeler Stefanie
Abstract excerpt
RATIONALE: Aging represents a major risk factor for coronary artery disease and aortic aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of biological processes, but their role in age-associated vascular pathologies is unknown. OBJECTIVE: We aim to identify miRs in the vasculature that are regulated by age and play a role in age-induced vascular pathologies. METHODS AND RESULTS: Expression...
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