Article
Mitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance.
The Journal of biological chemistry - 21 Oct 2011
Ganguly Anutosh, Yang Hailing, Pedroza Mesias, Bhattacharya Rajat, Cabral Fernando
Abstract excerpt
Paclitaxel has powerful anticancer activity, but some tumors are inherently resistant to the drug, whereas others are initially sensitive but acquire resistance during treatment. To deal with this problem, it will be necessary to understand the mechanisms of drug action and resistance. Recent studies indicate that paclitaxel blocks cell division by inhibiting the detachment of microtubules from centrosomes. Here,...
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