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Retinoic Acid and Affective Disorders

22 Aug 2011

Abstract excerpt

OBJECTIVE: Isotretinoin (13-cis-retinoic acid), approved by the US Food and Drug Administration for the treatment of acne, carries a black box warning related to the risk of depression, suicide, and psychosis. Retinoic acid, the active form of vitamin A, regulates gene expression in the brain, and isotretinoin is its 13-cis isomer. Retinoids represent a group of compounds derived from vitamin A that perform a...

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PMID: 21903028
DOI: 10.4088/jcp.10r05993

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