Article

Potential depression and antidepressant-response biomarkers in human lymphoblast cell lines from treatment-responsive and treatment-resistant subjects: roles of SSRIs and omega-3 polyunsaturated fatty acids

2020-01-23

Abstract excerpt

While several therapeutic strategies exist for depression, most antidepressant drugs require several weeks before reaching full biochemical efficacy and remission is not entirely achieved in many patients. Therefore, biomarkers for depression and drug-response would help tailor treatment strategies. This study made use of banked human lymphoblast cell lines (LCLs) from normal and depressed subjects; the latter div...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb0c8b79-4154-5a51-bb2a-8245efc30c60
DOI: 10.1101/2020.01.22.914358

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Potential depression and antidepressant-response biomarkers in human lymphoblast cell lines from treatment-responsive and treatment-resistant subjects: roles of SSRIs and omega-3 polyunsaturated fatty acidsDOI 10.1101/2020.01.22.914358Read

Beyond the resistance: how novel neurobiological understandings of depression may lead to advanced treatment strategies.Semantic proximity Read

Investigating the inflammatory phenotype of major depression: focus on cytokines and polyunsaturated fatty acids.Semantic proximity Read

Depression pathogenesis and treatment: what can we learn from blood mRNA expression?Semantic proximity Read

Genome-wide Expression Profiling of Human Lymphoblastoid Cell Lines Identifies CHL1 as a Putative SSRI Antidepressant Response BiomarkerSemantic proximity Read

From Immune Activation to Cell Death: Investigating the Pro-inflammatory Phenotype of PBMCs in Major Depressive DisorderSemantic proximity Read

Omega 3 polyunsaturated fatty acids and the treatment of depression.Semantic proximity Read

Neurobiology of depression and novel antidepressant drug targets.Semantic proximity Read

Divergent transcriptomic profiles in depressed individuals with hyper- and hypophagia implicating inflammatory statusSemantic proximity Read

Distinct neuronal, proliferative, and secretory pathways are perturbed in cancer survivors with depressive symptomsSemantic proximity Read

Anti-Depression a Systematic Review of Analytical methods in PharmaceuticalsSemantic proximity Read

N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cellsSemantic proximity Read

Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling PathwaysSemantic proximity Read