Article
Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma.
The Journal of clinical investigation - 1 Jul 2001
Zeelenberg I S, Ruuls-Van Stalle L, Roos E
Abstract excerpt
The dissemination of T cell hybridomas to multiple nonhematopoietic tissues is blocked by pertussis toxin, suggesting the involvement of a chemokine. To study whether this chemokine is SDF-1, we employed a strategy proposed previously for gene therapy of AIDS, whereby the SDF-1 receptor CXCR4 (also a coreceptor for HIV) is retained in the endoplasmic reticulum (ER) and fails to reach the cell surface. We...
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