Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release.

Abstract excerpt

The ability of soluble forms of CD4 to induce gp120 release from the human immunodeficiency virus type 1 envelope glycoprotein complex may reflect molecular events associated with membrane fusion. The third hypervariable (V3) region of gp120 appears to play a role in fusion independent of CD4 binding. We demonstrate herein that envelope glycoprotein molecules rendered fusion defective by mutations in conserved...

Topics

• Animals
• Blotting, Western
• CD4 Antigens
• Cell Line
• Genes, Viral
• Giant Cells
• HIV Envelope Protein gp120
• HIV-1
• Membrane Fusion
• Mutation
• Peptide Fragments