Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels.

doi:10.1038/jhg.2011.105

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Article

Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels.

Journal of human genetics - 1 Nov 2011

Shen Haiqing, Damcott Coleen, Shuldiner Scott R, Chai Sumbul, Yang Rongze, Hu Hong, Gibson Quince, Ryan Kathleen A, Mitchell Braxton D, Gong Da-Wei

Abstract excerpt

We carried out a genome-wide association study of serum aspartate aminotransferase (AST) activity in 866 Amish participants of the Heredity and Phenotype Intervention Heart Study and identified significant association of AST activity with a cluster of single nucleotide polymorphisms located on chromosome 10q24.1 (peak association was rs17109512; P=2.80E-14), in the vicinity of GOT1, the gene encoding cytosolic...

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PMID: 21900944
DOI: 10.1038/jhg.2011.105
PMCID: PMC3608855

Genes

GOT1
MAF

Variants

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