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Experimentally controlled downregulation of the histone chaperone FACT inPlasmodium bergheireveals that it is critical to male gamete fertility

8 Sept 2011

Abstract excerpt

Human FACT (facilitates chromatin transcription) consists of the proteins SPT16 and SSRP1 and acts as a histone chaperone in the (dis)assembly of nucleosome (and thereby chromatin) structure during transcription and DNA replication. We identified a Plasmodium berghei protein, termed FACT-L, with homology to the SPT16 subunit of FACT. Epitope tagging of FACT-L showed nuclear localization with high expression in...

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PMID: 21899698
DOI: 10.1111/j.1462-5822.2011.01683.x

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