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Article

Topiramate and visual loss in a patient carrying a Leber hereditary optic neuropathy mutation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Apr 2012

Rinalduzzi Steno, Cipriani Anna Maria, Accornero Neri

Abstract excerpt

We describe a 43-year-old patient who experienced visual loss 4 years after beginning antiepileptic therapy with topiramate. Ophthalmological and neurological examinations led to a preliminary diagnosis of bilateral toxic optic neuritis. Mitochondrial genome sequence analysis detected a Leber hereditary optic neuropathy 11778G>A mutation. The possibility that topiramate might favor a conversion disease, alerts...

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PMID: 21898092
DOI: 10.1007/s10072-011-0755-5

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