Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical Characteristics of m.11778G>A Leber Hereditary Optic Neuropathy with Favorable Outcomes.

Seminars in ophthalmology - 1 May 2024

Samuel Kim Ungsoo, Yun Jeong Seop

Abstract excerpt

The prognosis of 11,778 mitochondrial mutations in Leber hereditary optic neuropathy (LHON) is poor. Patients with favorable outcomes (visual acuity better than 20/100) who could be observed for more than 6 months were analyzed. Among 74 patients (57 male, 17 female), 6 (8.1%) showed improvement in visual acuity of 20/100 or higher. The patients with favorable outcomes have better visual acuity at nadir (logMAR...

Topics

Humans
Male
Female
Infant
Adolescent
Young Adult
Adult
Optic Atrophy, Hereditary, Leber
Antioxidants
Prognosis
Mutation
Visual Acuity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA, Mitochondrial

Source

Identifiers

PMID: 38420942
DOI: 10.1080/08820538.2024.2323114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Characteristics of m.11778G>A Leber Hereditary Optic Neuropathy with Favorable Outcomes.PMID 38420942Read ↗

A Typical Case Presentation with Spontaneous Visual Recovery in Patient Diagnosed with Leber Hereditary Optic Neuropathy due to Rare Point Mutation in MT-ND4 Gene (m.11253T>C) and Literature Review.Semantic proximity Read ↗

Leber's hereditary optic neuropathy: course of disease in consideration of idebenone treatment and type of mutation.Semantic proximity Read ↗

Therapeutic benefit of idebenone in patients with Leber hereditary optic neuropathy: The LEROS nonrandomized controlled trial.Semantic proximity Read ↗

Leber’s hereditary optic neuropathy: Update on current diagnosis and treatmentSemantic proximity Read ↗

Clinical trials in Leber hereditary optic neuropathy: outcomes and opportunities.Semantic proximity Read ↗

Systematic review of Leber's hereditary optic neuropathy - Clinical diagnosis, genetics overview and current concepts of treatment.Semantic proximity Read ↗

Clinical features of Leber's hereditary optic neuropathy with the 11778 mitochondrial DNA mutation in Taiwanese patients.Semantic proximity Read ↗

[Research progress of Leber hereditary optic neuropathy].Semantic proximity Read ↗

Do idebenone and vitamin therapy shorten the time to achieve visual recovery in Leber hereditary optic neuropathy?Semantic proximity Read ↗

Clinical and Genetic Profile of Leber's Hereditary Optic Neuropathy in a Cohort of Patients From a Tertiary Eye Care Center.Semantic proximity Read ↗

Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre.Semantic proximity Read ↗

Leber's Hereditary Optic Neuropathy with Mitochondrial DNA Mutation G11778A: A Systematic Literature Review and Meta-Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.