Article
Prophylaxis for second eye involvement in leber hereditary optic neuropathy: an open-labeled, nonrandomized multicenter trial of topical brimonidine purite.
American journal of ophthalmology - 1 Sept 2005
Newman Nancy J, Biousse Valerie, David Robert, Bhatti M Tariq, Hamilton Steven R, Farris Bradley K, Lesser Robert L, Newman Steven A, Turbin Roger E, Chen Kuankuan, Keaney Robert P
Abstract excerpt
PURPOSE: To test a topical agent with purported antiapoptotic properties as prophylactic treatment after first eye involvement in Leber hereditary optic neuropathy (LHON), a maternally-inherited disorder characterized by bilateral, often sequential, visual loss. DESIGN: Open labeled, nonrandomized prospective pilot study. METHODS: Nine primary mutation molecularly confirmed LHON patients with one eye vision loss...
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