Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.

Nature genetics - 1 Jul 2001

Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I

Abstract excerpt

The cardiac homeobox protein Nkx2-5 is essential in cardiac development, and mutations in Csx (which encodes Nkx2-5) cause various congenital heart diseases. Using the yeast two-hybrid system with Nkx2-5 as the 'bait', we isolated the T-box-containing transcription factor Tbx5; mutations in TBX5 cause heart and limb malformations in Holt-Oram syndrome (HOS). Co-transfection of Nkx2-5 and Tbx5 into COS-7 cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Natriuretic Factor
Share to Heart Defects, Congenital
Share to Homeobox Protein Nkx-2.5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Limb Deformities, Congenital

Share to Myocardial Contraction

Share to Protein Precursors

Share to T-Box Domain Proteins

Share to Xenopus Proteins

Source

Identifiers

PMID: 11431700
DOI: 10.1038/90123

Genes

TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.PMID 11431700Read ↗

TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs).Semantic proximity Read ↗

Synergistic activation of cardiac genes by myocardin and Tbx5.Semantic proximity Read ↗

Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram syndrome via association with SC35.Semantic proximity Read ↗

A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery.Semantic proximity Read ↗

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.Semantic proximity Read ↗

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development.Semantic proximity Read ↗

Congenital heart disease caused by mutations in the transcription factor NKX2-5.Semantic proximity Read ↗

The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.Semantic proximity Read ↗

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.Semantic proximity Read ↗

Identification of the TBX5 transactivating domain and the nuclear localization signal.Semantic proximity Read ↗

Functional analysis of novel TBX5 T-box mutations associated with Holt-Oram syndrome.Semantic proximity Read ↗

A novel TBX5 mutation predisposes to familial cardiac septal defects and atrial fibrillation as well as bicuspid aortic valveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.