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Article

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance

25 Feb 2020

Abstract excerpt

BACKGROUND: Differential expression of mucins has been associated with several cancers including colorectal cancer (CRC). In normal physiological conditions, secretory mucin MUC5AC is not expressed in the colonic mucosa, whereas its aberrant expression is observed during development of colon cancer and its precursor lesions. To date, the molecular mechanism of MUC5AC in CRC progression and drug resistance remains...

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PMID: 32098629
DOI: 10.1186/s12943-020-01156-y

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