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The influence of nutrient supply and cell density on the growth and survival of intervertebral disc cells in 3D culture

5 Sept 2011

Abstract excerpt

The adult human intervertebral disc (IVD) is normally avascular. Changes to the extracellular matrix in degenerative disc disease may promote vascularisation and subsequently alter cell nutrition and disc homeostasis. This study examines the influence of cell density and the presence of glucose and serum on the proliferation and survival of IVD cells in 3D culture. Bovine nucleus pulposus (NP) cells were seeded...

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PMID: 21892804
DOI: 10.22203/ecm.v022a08

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