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Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children.

Diabetes care - 1 Feb 2013

Parkkola Anna, Härkönen Taina, Ryhänen Samppa J, Ilonen Jorma, Knip Mikael

Abstract excerpt

OBJECTIVE: To determine the frequency of newly diagnosed diabetic children with first- and second-degree relatives affected by type 1 diabetes and to characterize the effects of this positive family history on clinical markers, signs of β-cell autoimmunity, and HLA genotype in the index case. RESEARCH DESIGN AND METHODS: Children (n = 1,488) with type 1 diabetes diagnosed under 15 years of age were included in a...

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Identifiers

PMID: 23033245
DOI: 10.2337/dc12-0445
PMCID: PMC3554291

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