Article
Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascular disease in patients with rheumatoid arthritis.
DNA and cell biology - 1 Jul 2012
García-Bermúdez Mercedes, López-Mejías Raquel, González-Juanatey Carlos, Castañeda Santos, Miranda-Filloy José A, Blanco Ricardo, Fernández-Gutiérrez Benjamín, Balsa Alejandro, González-Alvaro Isidoro, Gómez-Vaquero Carmen, Llorca Javier, Martín Javier, González-Gay Miguel A
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Toll-like receptor-4 (TLR4) activates the innate immune response via NF-kB pathway and mitogen-activated protein kinase signaling, leading to expression of proinflammatory cytokines and chemokines. The G allele of TLR4 rs4986790 (+896A>G, Asp299Gly) gene polymorphism has been implicated in...
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