Article
Rectification of the channelrhodopsin early conductance.
Biophysical journal - 7 Sept 2011
Gradmann Dietrich, Berndt André, Schneider Franziska, Hegemann Peter
Abstract excerpt
We analyzed the nonlinear current-voltage relationships of the early conducting state of channelrhodopsin-2 expressed in Xenopus oocytes and human embryonic kidney cells with respect to changes of the electrochemical gradients of H(+), Na(+)/K(+), and Ca(2+)/Mg(2+). Several models were tested for wild-type ChR2 and mutations at positions E90, E123, H134, and T159. Voltage-gating was excluded as cause for the...
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