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Article

In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 1 Nov 2014

Loewe Axel, Lutz Yannick, Wilhelms Mathias, Sinnecker Daniel, Barthel Petra, Scholz Eberhard P, Dössel Olaf, Schmidt Georg, Seemann Gunnar

Abstract excerpt

AIMS: The clinical efficacy in preventing the recurrence of atrial fibrillation (AF) is higher for amiodarone than for dronedarone. Moreover, pharmacotherapy with these drugs is less successful in patients with remodelled substrate induced by chronic AF (cAF) and patients suffering from familial AF. To date, the reasons for these phenomena are only incompletely understood. We analyse the effects of the drugs in a...

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Identifiers

PMID: 25362168
DOI: 10.1093/europace/euu230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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