Article
Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.
The Journal of molecular diagnostics : JMD - 1 Nov 2011
Tian Yongji, Rich Benjamin E, Vena Natalie, Craig Justin M, Macconaill Laura E, Rajaram Veena, Goldman Stewart, Taha Hala, Mahmoud Madeha, Ozek Memet, Sav Aydin, Longtine Janina A, Lindeman Neal I, Garraway Levi A, Ligon Azra H, Stiles Charles D, Santagata Sandro, Chan Jennifer A, Kieran Mark W, Ligon Keith L
Abstract excerpt
Alterations of BRAF are the most common known genetic aberrations in pediatric gliomas. They frequently are found in pilocytic astrocytomas, where genomic duplications involving BRAF and the poorly characterized gene KIAA1549 create fusion proteins with constitutive B-Raf kinase activity. BRAF V600E point mutations are less common and generally occur in nonpilocytic tumors. The development of BRAF inhibitors as...
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