Article
Molecular pathology of tumor-initiating cells: lessons from Philadelphia chromosome-positive leukemia.
Pathology international - 1 Sept 2011
Naka Kazuhito, Hoshii Takayuki, Tadokoro Yuko, Hirao Atsushi
Abstract excerpt
Recent improvements in cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor-initiating cells (TIC). This discovery has led to the 'cancer stem cell hierarchy' concept, which holds that tumors are organized as a hierarchy of malignant tissues sustained by such TIC. However, this concept remains controversial. In this review, we examine recent...
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