New Complexes of Copper (II) and Zoledronic Acid: Relevance to Oxidative Death of Leukemia Cells in the Bone Marrow

Abstract excerpt

Copper-organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the tu...

Topics

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• Computational Drug Discovery Methods
• Drug Transport and Resistance Mechanisms
• Ferrocene Chemistry and Applications
• Metal complexes synthesis and properties
• Peptidase Inhibition and Analysis
• Pharmacological Effects and Toxicity Studies
• Trace Elements in Health
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

0a1af164-e602-59fa-837e-991ee48e1a38

DOI

10.20944/preprints202601.1136.v1