Article
The mitochondrion: a perpetrator of acquired hearing loss.
Hearing research - 1 Sept 2013
Böttger Erik C, Schacht Jochen
Abstract excerpt
Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably less information available as to the mechanisms underlying ROS formation. Most cellular ROS arise in mitochondria and this review will evaluate evidence for mitochondrial pathology in general and dysfunction of the mitochondrial...
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