Article
Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.
Molecular cancer therapeutics - 1 Nov 2011
Uhmann Anja, Niemann Hannah, Lammering Bérénice, Henkel Cornelia, Hess Ina, Nitzki Frauke, Fritsch Anne, Prüfer Nicole, Rosenberger Albert, Dullin Christian, Schraepler Anke, Reifenberger Julia, Schweyer Stefan, Pietsch Torsten, Strutz Frank, Schulz-Schaeffer Walter, Hahn Heidi
Abstract excerpt
Activation of the Hedgehog (Hh)-signaling pathway due to deficiency in the Hh receptor Patched1 (Ptch) is the pivotal defect leading to formation of basal cell carcinoma (BCC). Recent reports provided evidence of Ptch-dependent secretion of vitamin D(3)-related compound, which functions as an endogenous inhibitor of Hh signaling by repressing the activity of the signal transduction partner of Ptch, Smoothened...
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