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Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A

11 Jun 2009

Abstract excerpt

The activation of type I IFN signaling is a major component of host defense against viral infection, but it is not typically associated with immune responses to extracellular bacterial pathogens. Using mouse and human airway epithelial cells, we have demonstrated that Staphylococcus aureus activates type I IFN signaling, which contributes to its virulence as a respiratory pathogen. This response was dependent on...

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PMID: 19603548
DOI: 10.1172/jci35879

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