Article
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
Molecular psychiatry - 1 Nov 2012
Amin N, Byrne E, Johnson J, Chenevix-Trench G, Walter S, Nolte I M, Vink J M, Rawal R, Mangino M, Teumer A, Keers J C, Verwoert G, Baumeister S, Biffar R, Petersmann A, Dahmen N, Doering A, Isaacs A, Broer L, Wray N R, Montgomery G W, Levy D, Psaty B M, Gudnason V, Chakravarti A, Sulem P, Gudbjartsson D F, Kiemeney L A, Thorsteinsdottir U, Stefansson K, van Rooij F J A, Aulchenko Y S, Hottenga J J, Rivadeneira F R, Hofman A, Uitterlinden A G, Hammond C J, Shin S-Y, Ikram A, Witteman J C M, Janssens A C J W, Snieder H, Tiemeier H, Wolfenbuttel B H R, Oostra B A, Heath A C, Wichmann E, Spector T D, Grabe H J, Boomsma D I, Martin N G, van Duijn C M
Abstract excerpt
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis treating different cell lines with caffeine. Genome-wide significant association was observed for two...
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