Article
Evidence of association between methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a candidate-gene association study in a South-eastern European population.
DNA and cell biology - 1 Feb 2012
Papandreou Christos N, Doxani Chrysa, Zdoukopoulos Nikos, Vlachostergios Panagiotis J, Hatzidaki Eleana, Bakalos Georgios, Ziogas Dimitris C, Koufakis Theocharis, Zintzaras Elias
Abstract excerpt
The methylenetetrahydrofolate reductase (MTHFR) gene has been proposed as a candidate gene for breast cancer (BC). However, the specific role of MTHFR polymorphisms and haplotypes has not been fully clarified and replicated. We examined the association of two common MTHFR polymorphisms (C677T and A1298C) and their haplotypes in a candidate-gene association study, involving 300 female patients with BC and 283...
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