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Article

Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.

Cancer genetics - 1 Jul 2011

Kamino Hiroki, Moore Rick, Negishi Masahiko

Abstract excerpt

Phenobarbital (PB), a nongenotoxic carcinogen, activates the nuclear constitutive active/androstane receptor (CAR), resulting in the transcriptional induction or repression of various hepatic genes. We previously demonstrated that liver tumors developed after chronic PB treatment only when CAR is present. To understand the molecular mechanism of tumor promotion, cDNA microarray analysis was performed. We...

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Share to Carcinoma, Hepatocellular
Share to Constitutive Androstane Receptor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms, Experimental

Share to Microscopy, Confocal

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Share to Receptors, Cytoplasmic and Nuclear

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Source

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Identifiers

PMID: 21872825
DOI: 10.1016/j.cancergen.2011.05.007
PMCID: PMC3178051

Genes

TUBA8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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