Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila.

doi:10.1007/s12041-011-0062-1

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Article

Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila.

Journal of genetics - 1 Aug 2011

Ayyub Champakali

Abstract excerpt

Cullins confer substrate specificity to E3-ligases which are multi-protein complexes involved in ubiquitin-mediated protein degradation or modification. There are six cullin genes in Drosophila melanogaster. We have raised an antibody against Cul-5 and demonstrated that it expresses in neuronal and non-neuronal cells throughout development. In the embryonic tracheal system, Cul-5 is enriched at fusion sites...

Topics

Amino Acid Sequence
Animals
Cullin Proteins
Drosophila Proteins
Drosophila melanogaster
Female
Gene Components
Gene Knockout Techniques
Larva
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Insertional

Neuromuscular Junction

Oogenesis

Organ Specificity

Ovary

Phenotype

Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 21869472
DOI: 10.1007/s12041-011-0062-1

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