Article
Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila.
Journal of genetics - 1 Aug 2011
Ayyub Champakali
Abstract excerpt
Cullins confer substrate specificity to E3-ligases which are multi-protein complexes involved in ubiquitin-mediated protein degradation or modification. There are six cullin genes in Drosophila melanogaster. We have raised an antibody against Cul-5 and demonstrated that it expresses in neuronal and non-neuronal cells throughout development. In the embryonic tracheal system, Cul-5 is enriched at fusion sites...
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