Article
Association of DNA methylation and musculoskeletal spinal pain at four timepoints during adolescence and early adulthood.
Epigenomics - 1 Dec 2025
Beales Darren, Waller Robert, Chia Jasmine Yong Ning, Lim Liang Mu, Tan Howe Yong, Tan Jia Ling, Huang Rae-Chi, Straker Leon, Melton Phillip E
Abstract excerpt
BACKGROUND: This study examined the association between epigenetic genome-wide DNA methylation with mechanism-based phenotypes of spinal pain from adolescence through early adulthood, accounting for confounders. RESEARCH DESIGN AND METHODS: We investigated the relationship between the timing of spinal pain at 14, 17, 22, and 27 years and blood DNA methylation at 17 years in the Raine Study Gen2 cohort. We...
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