Intraperitoneal injection of 5-azacytidine alleviates nerve injury-induced chronic neuropathic pain in rats: the involvement of DNA methylation in the lumbar spinal cord

Abstract excerpt

<title>Abstract</title> <p>Aims To investigate the role of DNA methylation in modulating chronic neuropathic pain (NPP), identify possible target genes of DNA methylation involved in this process, and preliminarily confirm the medicinal value of the DNA methyltransferase (DNMT) inhibitor 5-azacytidine (5-AZA) in NPP by targeting gene methylation. Methods Two rat NPP models, chronic constriction injury (CCI) and...

Topics

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• Histone Deacetylase Inhibitors Research
• Nerve injury and regeneration
• Neurological diseases and metabolism
• Pain Management and Opioid Use
• Pain Mechanisms and Treatments
• Peptidase Inhibition and Analysis
• RNA modifications and cancer
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

e619a229-ce22-5cfc-a883-e1635eb28e0a

DOI

10.21203/rs.3.rs-2131664/v1