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Article

Regulation of the susceptibility of HIV-1 to a neutralizing antibody KD-247 by nonepitope mutations distant from its epitope.

AIDS (London, England) - 28 Nov 2011

Takizawa Mari, Miyauchi Kosuke, Urano Emiko, Kusagawa Shigeru, Kitamura Katsuhiko, Naganawa Satoshi, Murakami Toshio, Honda Mitsuo, Yamamoto Naoki, Komano Jun

Abstract excerpt

OBJECTIVE: A humanized neutralizing antibody, KD-247, targets the V3 loop of HIV-1 Env. HIV-1 bearing the GPGR sequence at the V3 loop is potentially susceptible to KD-247. However, not all GPGR-positive HIV-1 isolates are neutralized by KD-247. We examined the potential mechanism by which the susceptibility of HIV-1 to KD-247-mediated neutralization is regulated. DESIGN: We searched for nonepitope neutralization...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21866041
DOI: 10.1097/QAD.0b013e32834bab68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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