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Article

Resistance profile of a neutralizing anti-HIV monoclonal antibody, KD-247, that shows favourable synergism with anti-CCR5 inhibitors.

AIDS (London, England) - 24 Oct 2006

Yoshimura Kazuhisa, Shibata Junji, Kimura Tetsuya, Honda Akiko, Maeda Yosuke, Koito Atsushi, Murakami Toshio, Mitsuya Hiroaki, Matsushita Shuzo

Abstract excerpt

BACKGROUND: The high-affinity humanized monoclonal antibody (MAb) KD-247 reacts with a tip region in gp120-V3 and cross-neutralizes primary isolates with a matching neutralization sequence motif. METHODS: We induced an HIV-1 variant that was resistant to KD-247 by exposing the JR-FL virus to increasing concentrations of KD-247 in PM1/CCR5 cells, which expressed high levels of CCR5 in vitro. We determined the...

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Share to Anti-HIV Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCR5 Receptor Antagonists

Share to Dose-Response Relationship, Immunologic

Share to Drug Synergism

Share to HIV Envelope Protein gp120

Share to Peptide Fragments

Share to Receptors, CCR5

Source

Identifiers

PMID: 17053352
DOI: 10.1097/01.aids.0000247587.31320.fe

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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