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Article

Isolation of TAK-779-resistant HIV-1 from an R5 HIV-1 GP120 V3 loop library.

The Journal of biological chemistry - 26 Aug 2005

Yusa Keisuke, Maeda Yosuke, Fujioka Aki, Monde Kazuaki, Harada Shinji

Abstract excerpt

The human immunodeficiency virus (HIV-1) envelope glycoprotein (GP) 120 interacts with CD4 and the CCR5 coreceptor for viral entry. The V3 loop in GP120 is a crucial region for determining coreceptor usage during viral entry, and a variety of amino acid substitutions has been observed in clinical isolates. To construct an HIV-1 V3 loop library, we chose 10 amino acid positions in the V3 loop and incorporated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15983047
DOI: 10.1074/jbc.M414360200

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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