Article
Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.
PloS one - 1 Jan 2014
Langevin Stanley A, Bowen Richard A, Reisen William K, Andrade Christy C, Ramey Wanichaya N, Maharaj Payal D, Anishchenko Michael, Kenney Joan L, Duggal Nisha K, Romo Hannah, Bera Aloke Kumar, Sanders Todd A, Bosco-Lauth Angela, Smith Janet L, Kuhn Richard, Brault Aaron C
Abstract excerpt
A single helicase amino acid substitution, NS3-T249P, has been shown to increase viremia magnitude/mortality in American crows (AMCRs) following West Nile virus (WNV) infection. Lineage/intra-lineage geographic variants exhibit consistent amino acid polymorphisms at this locus; however, the majority of WNV isolates associated with recent outbreaks reported worldwide have a proline at the NS3-249 residue. In order...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.