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Article

West Nile Virus Temperature Sensitivity and Avian Virulence Are Modulated by NS1-2B Polymorphisms.

PLoS neglected tropical diseases - 1 Aug 2016

Dietrich Elizabeth A, Langevin Stanley A, Huang Claire Y-H, Maharaj Payal D, Delorey Mark J, Bowen Richard A, Kinney Richard M, Brault Aaron C

Abstract excerpt

West Nile virus (WNV) replicates in a wide variety of avian species, which serve as reservoir and amplification hosts. WNV strains isolated in North America, such as the prototype strain NY99, elicit a highly pathogenic response in certain avian species, notably American crows (AMCRs; Corvus brachyrhynchos). In contrast, a closely related strain, KN3829, isolated in Kenya, exhibits a low viremic response with...

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PMID: 27548738
DOI: 10.1371/journal.pntd.0004938
PMCID: PMC4993437

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