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Article

Association of MMP-3 (-1612 5A/6A) polymorphism with knee osteoarthritis in Thai population.

Rheumatology international - 1 Feb 2013

Honsawek Sittisak, Malila Somkiat, Yuktanandana Pongsak, Tanavalee Aree, Deepaisarnsakul Benjamad, Parvizi Javad

Abstract excerpt

Osteoarthritis (OA) is a degenerative joint disorder resulting in destruction of articular cartilage, osteophyte formation, and subchondral bone sclerosis. In recent years, numerous genetic factors have been identified and implicated in causing osteoarthritis. One such genetic defect is a single nucleotide polymorphism at position -1612 of matrix metalloproteinase-3 (MMP-3) promoter region, known to lead to three...

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Identifiers

PMID: 22457004
DOI: 10.1007/s00296-012-2371-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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