Article
Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops.
BMC biochemistry - 23 Aug 2011
Giacopuzzi Edoardo, Barlati Sergio, Preti Augusto, Venerando Bruno, Monti Eugenio, Borsani Giuseppe, Bresciani Roberto
Abstract excerpt
BACKGROUND: Large surface loops contained within compact protein structures and not involved in catalytic process have been proposed as preferred regions for protein family evolution. These loops are subjected to lower sequence constraints and can evolve rapidly in novel structural variants. A good model to study this hypothesis is represented by sialidase enzymes. Indeed, the structure of sialidases is a...
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