[Effect of rs2293347 Polymorphism in EGFR on the Clinical Efficacy of Gefitinib  in Patients with Non-small Cell Lung Cancer].

doi:10.3779/j.issn.1009-3419.2011.08.02

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[Effect of rs2293347 Polymorphism in EGFR on the Clinical Efficacy of Gefitinib  in Patients with Non-small Cell Lung Cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer - 1 Aug 2011

Ma Fei, Xu Binghe, Lin Dongxin, Sun Tong, Shi Yuankai

Abstract excerpt

BACKGROUND: Genetic variations of the epidermal growth factor receptor (EGFR) may alter the protein function and therapeutic efficacy of EGFR inhibitors. The aim of this study is to investigate the association between single nucleotide polymorphism rs2293347 in EGFR and the clinical outcome in patients with advanced non-small cell lung cancer (NSCLC) treated with gefitinib. METHODS: A total of 88 advanced NSCLC...

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PMID: 21859544
DOI: 10.3779/j.issn.1009-3419.2011.08.02
PMCID: PMC5999630

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EGFR

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