Article

Effects of the ABCG2 C421A Polymorphism on Plasma Gefitinib Concentration

2019-07-05

Abstract excerpt

<h4>Background: </h4> In patients with epidermal growth factor (EGFR) exon 21 L858R mutation-positive non-small cell lung cancer (NSCLC) treated with gefitinib, we found that a lower plasma gefitinib concentration was associated with shorter progression-free survival (PFS). ATP-binding castle protein G2 (ABCG2) is considered to inhibit the activities of certain gefitinib transporters, which affects drug pharmacoki...

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Literature Corpus work: 4ac84ff3-219e-56ba-a774-aac7f8ed9b90
DOI: 10.21203/rs.2.10916/v1

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