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Article

Implicating calpain in tau-mediated toxicity in vivo.

PloS one - 1 Jan 2011

Reinecke James B, DeVos Sarah L, McGrath James P, Shepard Amanda M, Goncharoff Dustin K, Tait Don N, Fleming Samantha R, Vincent Michael P, Steinhilb Michelle L

Abstract excerpt

Alzheimer's disease and other related neurodegenerative disorders known as tauopathies are characterized by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identified a 17 kD proteolytic fragment of tau in degenerating neurons and in numerous cell culture models that is generated by calpain cleavage and speculated to...

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Identifiers

PMID: 21858230
DOI: 10.1371/journal.pone.0023865
PMCID: PMC3157467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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