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Article

Unbalanced transmethylation and the perturbation of the differentiated state leading to cancer.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Apr 1990

Hoffman R M

Abstract excerpt

It is proposed that the perturbation of the differentiated state in cancer is related to alterations in DNA methylation as well as to alterations in methylation of other cellular molecules, leading to an imbalance in global cellular methylation. It is hypothesized that the global imbalance in methylation is reflected in the enhanced levels of transmethylation seen in many cancer cell types as well as in a number...

Topics

Animals
DNA, Neoplasm
Genotype
Humans
Methionine
Methylation
Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2185747
DOI: 10.1002/bies.950120404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2185747-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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