Differentiation arrest by autologously replicating DNA loops formed along differentiation pathway: an hypothesis of carcinogenesis.

doi:10.1016/s0306-9877(96)90452-1

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Article

Differentiation arrest by autologously replicating DNA loops formed along differentiation pathway: an hypothesis of carcinogenesis.

Medical hypotheses - 1 Aug 1996

Xue B H

Abstract excerpt

The current hypothesis attempts to explain tumor development from the perspective of deoxyribonucleic acid structural changes rather than mutational alterations of single or multiple genes. The hypothesis postulates that stable deoxyribonucleic acid loops capable of autologous replication, transl...

Topics

Animals
Cell Differentiation
Cell Transformation, Neoplastic
DNA
DNA Replication
Gene Expression
Humans
Models, Biological
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms
Phenotype

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