Article
A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.
Cancer research - 1 Oct 2011
Gasparre Giuseppe, Kurelac Ivana, Capristo Mariantonietta, Iommarini Luisa, Ghelli Anna, Ceccarelli Claudio, Nicoletti Giordano, Nanni Patrizia, De Giovanni Carla, Scotlandi Katia, Betts Christine M, Carelli Valerio, Lollini Pier Luigi, Romeo Giovanni, Rugolo Michela, Porcelli Anna Maria
Abstract excerpt
The oncogenic versus suppressor roles of mitochondrial genes have long been debated. Peculiar features of mitochondrial genetics such as hetero/homoplasmy and mutation threshold are seldom taken into account in this debate. Mitochondrial DNA (mtDNA) mutations generally have been claimed to be protumorigenic, but they are also hallmarks of mostly benign oncocytic tumors wherein they help reduce adaptation to...
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