Article
Functional polymorphisms in PIN1 promoter and esophageal carcinoma susceptibility in Chinese population.
Molecular biology reports - 1 Feb 2013
You Yonghe, Deng Jieqiong, Zheng Jian, Jiang Lan, Li Na, Wu Hongchun, Li Wei, Lu Jiachun, Zhou Yifeng, Ni Bin
Abstract excerpt
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), which regulates the conformation of Pro-directed phosphorylation sites, has been identified as a critical catalyst involved in multiple oncogenic signaling pathways. Recently, it has been demonstrated that several putative functional polymorphisms of PIN1 gene were associated with cancer risk. This study examined whether genetic polymorphisms in...
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